Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (2024)

Table of Contents
Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide References

J Appl Biomed 17:136-145, 2019|DOI:10.32725/jab.2019.009

Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide

Petr Jost, Jaroslav Pejchal *, Tomas Kucera, Lubica Muckova, Rudolf Stetina
University of Defense, Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, Hradec Králové, Czech Republic

2-chloroethyl ethyl sulfide (CEES) is a vesicant agent, commonly referred to half mustard due to its ability to form monofunctional adducts with DNA. In this study, we evaluated the chemoprotective potential of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate (MESNA) against CEES-induced geno- and cytotoxicity in human lung cell line A-549. MESNA, L-glutathione (GSH), thiourea, sodium thiosulfate, hexamethylenetetramine, 4-acetamidophenol, asoxime dichloride (HI-6), N-acetyl-L-cysteine (NAC), sodium pyruvate, myo-inositol, 3-aminobenzamide (3-AB), nicotinamide, and Nω-nitro-L-arginine methyl ester hydrochloride and combinations of these compounds with MESNA were applied 30 min before CEES. DNA alkylation was measured using modified comet assay 1 and 24 h after the exposure. Cell viability was determined using MTT assay at 24 and 72 h. The mono-therapeutical approach identified MESNA and GSH to provide significant chemoprotection. NAC and 3-AB supported DNA damage repair, while cell viability remained unaffected. Mixtures of GSH or NAC with MESNA showed protective synergism against DNA damage. Other compounds or their combinations with MESNA failed due to the potentiation of CEES-induced cytotoxicity. The chemoprotection against CEES remains limited; however, the combination of substances can provide protective synergy and may represent a promising strategy in the treatment of accidental exposure to monoalkylating agents.

See Also
N Acetyl Cystein Vorteile | Was ist NAC? | Naturecan DEWhat’s the Best NAC Supplement? Experts Weigh In

Keywords: 2-chloroethyl ethyl sulfide; A-549 cell line; chemoprotection; comet assay; MESNA; MTT assay
Grants and funding:

The work was supported by the grant of The Ministry of Education, Youth and Sports of the Czech Republic No. SV/ FVZ20127 and long-term organization development plan Medical Aspects of Weapons of Mass Destruction of the Faculty of Military Health Sciences, University of Defense.

Conflicts of interest:

The authors declare that they have no conflict of interest.

Received: December 6, 2017; Accepted: June 3, 2019; Prepublished online: June 17, 2019; Published: June 28, 2019 Show citation

ACSAIPAPAASAHarvardChicagoIEEEISO690MLANLMTurabianVancouver

Jost P, Pejchal J, Kucera T, Muckova L, Stetina R. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide. J Appl Biomed. 2019;17(2):136-145. doi:10.32725/jab.2019.009. PubMed PMID:34907735.

Download citation

  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Abel EL, Bubel JD, Simper MS, Powell L, McClellan SA, Andreeff M, et al. (2011). Protection against 2-chloroethyl ethyl sulfide (CEES) - induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway. Toxicol Appl Pharmacol 255(2): 176-183. DOI: 10.1016/j.taap.2011.06.012. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (2)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (3)Go to PubMed...
    2. Andrew DJ, Lindsay CD (1998). Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by hexamethylenetetramine (HMT). Hum Exp Toxicol 17(7): 373-379. DOI: 10.1177/096032719801700703. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (4)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (5)Go to PubMed...
    3. Balali-Mood M, Hefazi M (2006). Comparison of early and late toxic effects of sulfur mustard in Iranian veterans. Basic Clin Pharmacol Toxicol 99(4): 273-282. DOI: 10.1111/j.1742-7843.2006.pto_429.x. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (6)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (7)Go to PubMed...
    4. Collins AR, Dusinská M, Horská A (2001). Detection of alkylation damage in human lymphocyte DNA with the comet assay. Acta Biochim Pol 48(3): 611-614. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (8)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (9)Go to PubMed...
    5. Croze ML, Soulage CO (2013). Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie 95(10): 1811-1827. DOI: 10.1016/j.biochi.2013.05.011. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (10)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (11)Go to PubMed...
    6. Debiak M, Lex K, Ponath V, Burckhardt-Boer W, Thiermann H, Steinritz D, et al. (2016). Immunochemical analysis of poly(ADP-ribosyl)ation in HaCaT keratinocytes induced by the mono-alkylating agent 2-chloroethyl ethyl sulfide (CEES): Impact of experimental conditions. Toxicol Lett 244: 72-80. DOI: 10.1016/j.toxlet.2015.09.009. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (12)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (13)Go to PubMed...
    7. Ferreira M, Assunção LS, Silva AH, Filippin-Monteiro FB, Creczynski-Pasa TB, Sá MM (2017). Allylic isothiouronium salts: The discovery of a novel class of thiourea analogues with antitumor activity. Eur J Med Chem 129: 151-158. DOI: 10.1016/j.ejmech.2017.02.013. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (14)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (15)Go to PubMed...
    8. Flanagan RJ, Meredith TJ (1991). Use of N-acetylcysteine in clinical toxicology. Am J Med 91(3C): 131S-139S. DOI: 10.1016/0002-9343(91)90296-A. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (16)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (17)Go to PubMed...
    9. Gould NS, White CW, Day BJ (2009). A role for mitochondrial oxidative stress in sulfur mustard analog 2-chloroethyl ethyl sulfide-induced lung cell injury and antioxidant protection. J Pharmacol Exp Ther 328(3): 732-739. DOI: 10.1124/jpet.108.145037. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (18)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (19)Go to PubMed...
    10. Graham GG, Scott KF (2005). Mechanism of action of paracetamol. Am J Ther 12(1): 46-55. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (20)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (21)Go to PubMed...
    11. Guzyk MM, Tykhomyrov AA, Nedzvetsky VS, Prischepa IV, Grinenko TV, Yanitska LV, Kuchmerovska TM (2016). Poly(ADP-Ribose) polymerase-1 (PARP-1) inhibitors reduce reactivegliosis and improve angiostatin levels in retina of diabetic rats. Neurochem Res 41(10): 2526-2537. DOI: 10.1007/s11064-016-1964-3. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (22)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (23)Go to PubMed...
    12. Han S, Espinoza LA, Liao H, Boulares AH, Smulson ME (2004). Protection by antioxidants against toxicity and apoptosis induced by the sulphur mustard analog 2-chloroethylethyl sulphide (CEES) in Jurkat T cells and normal human lymphocytes. Br J Pharmacol 141(5): 795-802. DOI: 10.1038/sj.bjp.0705591. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (24)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (25)Go to PubMed...
    13. Hara Y, McKeehan N, Dacks PA, Fillit HM (2017). Evaluation of the neuroprotective potential of N-acetylcysteine for prevention and treatment of cognitive aging and dementia. J Prev Alzheimers Dis 4(3): 201-206. DOI: 10.14283/jpad.2017.22. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (26)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (27)Go to PubMed...
    14. Institute of Medicine (US) Committee on the Survey of the Health Effects of Mustard Gas and Lewisite; Pechura CM, Rall DP (Eds.) (1993). Veterans at Risk: The Health Effects of Mustard Gas and Lewisite. Chemistry of Sulfur Mustard and Lewisite. Washington DC: National Academies Press (US). DOI: 10.17226/2058. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (28)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (29)Go to PubMed...
    15. Inturi S, Tewari-Singh N, Gu M, Shrotriya S, Gomez J, Agarwal C, et al. (2011). Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts. Free Radic Biol Med 51(12): 2272-2280. DOI: 10.1016/j.freeradbiomed.2011.08.020. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (30)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (31)Go to PubMed...
    16. Jain AK, Tewari-Singh N, Gu M, Inturi S, White CW, Agarwal R (2011). Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin. Toxicol Lett 205(3): 293-301. DOI: 10.1016/j.toxlet.2011.06.019. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (32)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (33)Go to PubMed...
    17. Jost P, Fikrova P, Svobodova H, Pejchal J, Stetina R (2017). Protective potential of different compounds and their combinations with MESNA against sulfur mustard-induced cytotoxicity and genotoxicity. Toxicol Lett 275: 92-100. DOI: 10.1016/j.toxlet.2017.05.010. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (34)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (35)Go to PubMed...
    18. Jost P, Svobodova H, Stetina R (2015). Induction and repair of DNA cross-links induced by sulfur mustard in the A-549 cell line followed by a comet assay. Chem Biol Interact 237: 31-37. DOI: 10.1016/j.cbi.2015.05.009. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (36)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (37)Go to PubMed...
    19. Kehe K, Raithel K, Kreppel H, Jochum M, Worek F, Thiermann H (2008). Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells. Arch Toxicol 82(7): 461-470. DOI: 10.1007/s00204-007-0265-7. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (38)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (39)Go to PubMed...
    20. Kehe K, Schrettl V, Thiermann H, Steinritz D (2013). Modified immunoslotblot assay to detect hemi and sulfur mustard DNA adducts. Chem Biol Interact 206(3): 523-528. DOI: 10.1016/j.cbi.2013.08.001. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (40)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (41)Go to PubMed...
    21. Kładna A, Marchlewicz M, Piechowska T, Kruk I, Aboul-Enein HY (2015). Reactivity of pyruvic acid and its derivatives towards reactive oxygen species. Lumin. J Biol Chem Lumin 30(7): 1153-1158. DOI: 10.1002/bio.2879. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (42)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (43)Go to PubMed...
    22. Kuča K, Musílek K, Jun D, Pohanka M, Karasová JZ, Novotný L, Musilová L (2009). Could oxime HI-6 really be considered as "broad-spectrum" antidote? J Appl Biomed 7(3): 143-149. DOI: 10.32725/jab.2009.016. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (44)Go to original source...
    23. Lindsay CD, Hambrook JL (1997). Protection of A549 cells against the toxic effects of sulphur mustard by hexamethylenetetramine. Hum Exp Toxicol 16(2): 106-114. DOI: 10.1177/096032719701600206. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (45)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (46)Go to PubMed...
    24. Maher P (2017). Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age-related neurodegenerative diseases. Free Radic Biol Med 115: 92-104. DOI: 10.1016/j.freeradbiomed.2017.11.015. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (47)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (48)Go to PubMed...
    25. Matz EL, Hsieh MH (2017). Review of advances in uroprotective agents for cyclophosphamide- and ifosfamide-induced hemorrhagic cystitis. Urology 100: 16-19. DOI: 10.1016/j.urology.2016.07.030. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (49)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (50)Go to PubMed...
    26. McClintock SD, Till GO, Smith MG, Ward PA (2002). Protection from half-mustard-gas-induced acute lung injury in the rat. J Appl Toxicol 22(4): 257-262. DOI: 10.1002/jat.856. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (51)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (52)Go to PubMed...
    27. Meier HL, Johnson JB (1992). The determination and prevention of cytotoxic effects induced in human lymphocytes by the alkylating agent 2,2'-dichlorodiethyl sulfide (sulfurmustard, HD). Toxicol Appl Pharmacol 113(2): 234-239. DOI: 10.1016/0041-008X(92)90119-D. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (53)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (54)Go to PubMed...
    28. Mosmann T (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65(1-2): 55-63. DOI: 10.1016/0022-1759(83)90303-4. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (55)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (56)Go to PubMed...
    29. Nakad R, Schumacher B (2016). DNA damage response and immune defense: links and mechanisms. Front Genet 7: 147. DOI: 10.3389/fgene.2016.00147. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (57)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (58)Go to PubMed...
    30. Palmieri M, Papale P, Della Ragione A, Quaranta G, Russo, G, Russo S (2016). In Vitro Antioxidant treatment of sem*n samples in assisted reproductive technology: effects of myo-inositol on nemaspermic parameters. Int J Endocrinol 2016: ID 2839041. DOI: 10.1155/2016/2839041. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (59)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (60)Go to PubMed...
    31. Paromov V, Qui M, Yang H, Smith M, Stone WL (2008). The influence of N-acetyl-L-cysteine on oxidative stress and nitric oxide synthesis in stimulated macrophages treated with a mustard gas analogue. BMC Cell Biol 9: 33. DOI: 10.1186/1471-2121-9-33. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (61)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (62)Go to PubMed...
    32. Rappeneau S, Baeza-Squiban A, Marano F, Calvet J (2000). Efficient protection of human bronchial epithelial cells against sulfur and nitrogen mustard cytotoxicity using drug combinations. Toxicol Sci 58(1): 153-160. DOI: 10.1093/toxsci/58.1.153. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (63)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (64)Go to PubMed...
    33. Ravindran S, Boovarahan SR, Shanmugam K, Vedarathinam RC, Kurian GA (2017). Sodium thiosulfate preconditioning ameliorates ischemia/reperfusion injury in rat hearts via reduction of oxidative stress and apoptosis. Cardiovasc Drugs Ther 31(5-6): 511-524. DOI: 10.1007/s10557-017-6751-0. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (65)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (66)Go to PubMed...
    34. Sagar S, Kumar P, Behera RR, Pal A (2014). Effects of CEES and LPS synergistically stimulate oxidative stress inactivates OGG1 signaling in macrophage cells. J Hazard Mater 278: 236-249. DOI: 10.1016/j.jhazmat.2014.05.096. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (67)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (68)Go to PubMed...
    35. Sagar S, Parida SR, Sabnam S, Rizwan H, Pal S, Swain MM, Pal A (2017). Increasing NO level regulates apoptosis and inflammation in macrophages after 2-chloroethyl ethyl sulphide challenge. Int J Biochem Cell Biol 83: 1-14. DOI: 10.1016/j.biocel.2016.12.004. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (69)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (70)Go to PubMed...
    36. Sawyer TW (1999). Synergistic protective effects of selected arginine analogues against sulphur mustard toxicity in neuron culture. Toxicol Appl Pharmacol 155(2): 169-176. DOI: 10.1006/taap.1998.8588. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (71)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (72)Go to PubMed...
    37. Sawyer TW, McNeely K, Louis K, Lecavalier P, Song Y, Villanueva M, Clewley R (2017). Comparative toxicity of mono- and bifunctional alkylating hom*ologues of sulphur mustard in human skin keratinocytes. Toxicology 382: 36-46. DOI: 10.1016/j.tox.2017.03.005. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (73)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (74)Go to PubMed...
    38. Schulmeister L (2008). Managing vesicant extravasations. Oncologist 13(3): 284-288. DOI: 10.1634/theoncologist.2007-0191. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (75)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (76)Go to PubMed...
    39. Srivastava AK, Srivastava S, Penna S, D'Souza SF (2011). Thiourea orchestrates regulation of redox state and antioxidant responses to reduce the NaCl-induced oxidative damage in Indian mustard [Brassica juncea (L.) Czern.]. Plant Physiol Biochem 49(6): 676-686. DOI: 10.1016/j.plaphy.2011.02.016. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (77)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (78)Go to PubMed...
    40. Tewari-Singh N, Inturi S, Jain AK, Agarwal C, Orlicky DJ, White CW, et al. (2014). Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide associated cutaneous toxic effects. Free Radic Biol Med 72: 285-295. DOI: 10.1016/j.freeradbiomed.2014.04.022. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (79)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (80)Go to PubMed...
    41. Wasil M, Halliwell B, Grootveld M, Moorhouse CP, Hutchison DC, Baum H (1987). The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Their protection of alpha 1-antiproteinase against inactivation by hypochlorous acid. Biochem J 243(3): 867-870. DOI: 10.1042/bj2430867. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (81)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (82)Go to PubMed...
    42. Yiannakopoulou E, Nikiteas N, Perrea D, Tsigris C (2012). Pharmacological modulation of oxidative stress response in minimally invasive surgery: systematic review. Surg Laparosc Endosc Percutan Tech 22(3): 200-204. DOI: 10.1097/SLE.0b013e318247d15e. Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (83)Go to original source... Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (84)Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content

    Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide (2024)
    Top Articles
    44 Orangetheory Fitness jobs in Canada
    Harbor Freight Coupon: All Items Under $10 (Online or In-Store) 30% Off (valid thru 06/30)
    Who Has Better Gas Prices: Costco or Sam's Club?
    Obituaries Kankakee Daily Journal
    Iron Bull 8.5x16 14K Deckover Dump Trailer - DDP - trailers - by dealer - vehicle automotive sale - craigslist
    Jesus Ortiz Paz Net Worth 2024: Age, Girlfriend, Family, Wife
    Temple University 1098 Form
    How To Get 1098 T Form Grand Canyon University - Nationalparklore.com
    NBA 2K24 All-in-One Complete Badges, Takeover, Badge Requirements, Badge Perks Guide, & Analysis
    The Definitive Guide to the Best Jumpshots in NBA 2K23 - DowneLink
    plasma donation centers near me in AZ
    HR Business Partner in Atlanta, Georgia, United States
    Latest Posts
    Fitness Coach - Orangetheory
    Orangetheory Fitness - Maverick Fitness Holdings, LLC hiring Member Ambassador - West Frisco in Frisco, Texas, United States | LinkedIn
    Article information

    Author: The Hon. Margery Christiansen

    Last Updated:

    Views: 6059

    Rating: 5 / 5 (50 voted)

    Reviews: 81% of readers found this page helpful

    Author information

    Name: The Hon. Margery Christiansen

    Birthday: 2000-07-07

    Address: 5050 Breitenberg Knoll, New Robert, MI 45409

    Phone: +2556892639372

    Job: Investor Mining Engineer

    Hobby: Sketching, Cosplaying, Glassblowing, Genealogy, Crocheting, Archery, Skateboarding

    Introduction: My name is The Hon. Margery Christiansen, I am a bright, adorable, precious, inexpensive, gorgeous, comfortable, happy person who loves writing and wants to share my knowledge and understanding with you.